Tuesday, April 14, 2009

Another Study Showing Adult Stem Cells Get Newly Diagnosed Diabetics Off of Insulin
















Great news: We have previously had human trials in which patients were weaned off of insulin with adult stem cells. Now, another study with newly diagnosed diabetes patients has achieved a similar success: And, it is written up in the Journal of the American Medical Association. From the abstract:

During a 7- to 58-month follow-up (mean, 29.8 months; median, 30 months), 20 patients without previous ketoacidosis and not receiving corticosteroids during the preparative regimen became insulin free. Twelve patients maintained this status for a mean 31 months (range, 14-52 months) and 8 patients relapsed and resumed insulin use at low dose (0.1-0.3 IU/kg)...Two patients developed bilateral nosocomial pneumonia, 3 patients developed late endocrine dysfunction, and 9 patients developed oligospermia. There was no mortality.

Conclusion After a mean follow-up of 29.8 months following autologous nonmyeloablative HSCT in patients with newly diagnosed type 1 DM, C-peptide levels increased significantly and the majority of patients achieved insulin independence with good glycemic control.

We know that if this were an embryonic stem cell success, the headlines would swamp reportage of the financial crisis. But this is the wrong kind of stem cell success, so I expect, at most, muted coverage. I'll keep an eye on how the media deal with (or ignore) this important breakthrough and report back tomorrow.

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8 Comments:

At April 14, 2009 , Blogger Jeremiah Films (Wayne) said...

I've linked to your post from Discerning Science - Human Life - Adult Stem Cells

 
At April 14, 2009 , Anonymous Anonymous said...

Interesting. Wesley, could you please explain, in non-researcher English, what the treatment entailed for those 12 patients?

 
At April 14, 2009 , Blogger Therese said...

Thanks so much for letting us know. My 9 year old child was diagnosed at 14 months with type one diabetes. I am almost certain that the cure for him will come from adult stem cells.

There is so many success stories with them.

 
At April 14, 2009 , Blogger Wesley J. Smith said...

I can't read the whole paper because I am not a subscriber. I think they take out the adult stem cells, destroy the immune system with chemo, and then inject the adult cells so the body's immune system "reboots." Type 1 is an auto immune disease. They do the same thing with MS.

It is risky for a period of time when the immune system is down and the patient has to be in isolation.

But like I said, I am not sure on this protocol since I haven't read the whole paper.

 
At April 14, 2009 , Blogger SAFEpres said...

YAY adult stem cells!!!!!!

 
At April 15, 2009 , Anonymous Anonymous said...

"destroy the immune system with chemo"

Well gee golly that sure sounds like fun!

Thanks for clarifying. I was wondering if this was another form of lifetime therapy or a one time deal.

 
At April 15, 2009 , Blogger Wesley J. Smith said...

Becky: This is early research, and the illness may have a genetic component. Not known whether such treatments are permanent. That is why I don't use the word "cure." It's all too early to know.

 
At April 15, 2009 , Blogger Dark Swan said...

Wesley why do you constantly mislead your readership with your boo hoo attitude for a realm of research you support for all the wrong reasons - namely you shamelessly attempt to use ASCr as a political tool against ESCr.

Well cry wolf again if you like but this is as well reported as the stem cell advances using embryonic cells.


http://www.time.com/time/health/article/0,8599,1891122,00.htmlhttp://diabetes.webmd.com/news/20090414/stem-cells-promising-for-type-one-diabeteshttp://www.cnn.com/2009/HEALTH/04/15/stem.cells.diabetes/http://news.bbc.co.uk/2/hi/health/7999760.stmhttp://www.newscientist.com/article/mg20227043.200-stemcell-treatment-for-diabetes-really-does-seem-to-work.htmlhttp://health.usnews.com/articles/health/diabetes/2009/04/15/health-buzz-stem-cell-transplants-for-type-1-diabetes-and-other-health-news.htmlhttp://www.bloomberg.com/apps/news?pid=20601124&sid=aMs8JCz0sU5k&refer=homehttp://www.forbes.com/feeds/hscout/2009/04/14/hscout626051.htmlhttp://www.technologyreview.com/biomedicine/22465/

 

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