Another Study Showing Adult Stem Cells Get Newly Diagnosed Diabetics Off of Insulin

Great news: We have previously had human trials in which patients were weaned off of insulin with adult stem cells. Now, another study with newly diagnosed diabetes patients has achieved a similar success: And, it is written up in the Journal of the American Medical Association. From the abstract:
We know that if this were an embryonic stem cell success, the headlines would swamp reportage of the financial crisis. But this is the wrong kind of stem cell success, so I expect, at most, muted coverage. I'll keep an eye on how the media deal with (or ignore) this important breakthrough and report back tomorrow.During a 7- to 58-month follow-up (mean, 29.8 months; median, 30 months), 20 patients without previous ketoacidosis and not receiving corticosteroids during the preparative regimen became insulin free. Twelve patients maintained this status for a mean 31 months (range, 14-52 months) and 8 patients relapsed and resumed insulin use at low dose (0.1-0.3 IU/kg)...Two patients developed bilateral nosocomial pneumonia, 3 patients developed late endocrine dysfunction, and 9 patients developed oligospermia. There was no mortality.
Conclusion After a mean follow-up of 29.8 months following autologous nonmyeloablative HSCT in patients with newly diagnosed type 1 DM, C-peptide levels increased significantly and the majority of patients achieved insulin independence with good glycemic control.
Labels: Adult Stem Cell Research. Diabetes. Successful Human Trials.


8 Comments:
I've linked to your post from Discerning Science - Human Life - Adult Stem Cells
Interesting. Wesley, could you please explain, in non-researcher English, what the treatment entailed for those 12 patients?
Thanks so much for letting us know. My 9 year old child was diagnosed at 14 months with type one diabetes. I am almost certain that the cure for him will come from adult stem cells.
There is so many success stories with them.
I can't read the whole paper because I am not a subscriber. I think they take out the adult stem cells, destroy the immune system with chemo, and then inject the adult cells so the body's immune system "reboots." Type 1 is an auto immune disease. They do the same thing with MS.
It is risky for a period of time when the immune system is down and the patient has to be in isolation.
But like I said, I am not sure on this protocol since I haven't read the whole paper.
YAY adult stem cells!!!!!!
"destroy the immune system with chemo"
Well gee golly that sure sounds like fun!
Thanks for clarifying. I was wondering if this was another form of lifetime therapy or a one time deal.
Becky: This is early research, and the illness may have a genetic component. Not known whether such treatments are permanent. That is why I don't use the word "cure." It's all too early to know.
Wesley why do you constantly mislead your readership with your boo hoo attitude for a realm of research you support for all the wrong reasons - namely you shamelessly attempt to use ASCr as a political tool against ESCr.
Well cry wolf again if you like but this is as well reported as the stem cell advances using embryonic cells.
http://www.time.com/time/health/article/0,8599,1891122,00.htmlhttp://diabetes.webmd.com/news/20090414/stem-cells-promising-for-type-one-diabeteshttp://www.cnn.com/2009/HEALTH/04/15/stem.cells.diabetes/http://news.bbc.co.uk/2/hi/health/7999760.stmhttp://www.newscientist.com/article/mg20227043.200-stemcell-treatment-for-diabetes-really-does-seem-to-work.htmlhttp://health.usnews.com/articles/health/diabetes/2009/04/15/health-buzz-stem-cell-transplants-for-type-1-diabetes-and-other-health-news.htmlhttp://www.bloomberg.com/apps/news?pid=20601124&sid=aMs8JCz0sU5k&refer=homehttp://www.forbes.com/feeds/hscout/2009/04/14/hscout626051.htmlhttp://www.technologyreview.com/biomedicine/22465/
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