British Scientists Tout Future Cure for Blindness with ESCs: What Would You Do If It Really Works?
The headline of this story from the Times of London--"Blind to be Cure with Stem Cells"--is really putting the cart before the horse--it hasn't even been tried yet, after all. But such hype is par for the course. From the story:
British scientists have developed the world's first stem cell therapy to cure the most common cause of blindness. Surgeons predict it will become a routine, one-hour procedure that will be generally available in six or seven years' time.We have seen such stories planted in media before. But I think this one is notable because private money is being put into the development of the treatment--venture capital has been, heretofore, notably scarce in ESCR. Thus, I think it is fair to say that when a very big drug company puts money into a potential therapy, there is at least a decent chance it will work.
The treatment involves replacing a layer of degenerated cells with new ones created from embryonic stem cells...This week Pfizer, the world's largest pharmaceutical research company, will announce its financial backing to bring the therapy to patients. The treatment will tackle age-related macular degeneration (AMD), the most common cause of blindness.
And that brings up an important question for those who oppose ESCR. What if it works and bending our ethical views could lead to our seeing again, but staying true to our beliefs would mean continuing vision impairment? Being forced to choose between better health and proper ethics is a foreseeable consequence of opposing ESCR, fetal farming, therapeutic cloning, and the like.
Some people have already grappled seriously with this question. Mark Pickup is an extremely close friend. He suffers--literally--from advanced and progressing MS, and so this issue is not merely an interesting intellectual exercise to him. Mark has written very clearly that he would refuse to receive ESC therapy, even if it meant foregoing a total cure, because to do otherwise would violate his Catholic faith and implicate him in the termination of a human life. From his column: Here's the problem for someone like me: I do operate with moral constraints and conscience. My Christianity demands it. I cannot participate in, or take advantage of, therapies developed using embryonic stem cells. It is unacceptable for my life to get better at the expense of another.I strongly believe that using human life--even at the most nascent stages--as a mere natural resource is profoundly wrong, not only because of what it does but what it will lead to once society accepts using living human beings as mere instrumentalities. I hope if I am ever faced with this dilemma that I would have Mark's courage and ethical integrity to refuse to be complicit in such wrongdoing--but one never knows until the crisis comes.
Non-embryonic stem cell sources are fine. If, however, the therapy involves the killing of another human being in the form of an embryo then I must forego treatment, accept life in a wheelchair, and whatever lies in store for me with an aggressive, degenerative disease...
Is the allure of an embryonic stem cell therapy tempting? Absolutely! But I must resist and, with God's help, I will resist. It is better to lose the use of my body than to lose my humanity.
This is why it is far easier to simply go along with the utilitarian flow. People who do never find themselves in such a pickle.
No one said that living an ethical life was easy. But as these issues play out, now is the time to think very deeply about the many "what ifs" that may confront us in the years to come: Because pondering these matters well before the time of testing offers the best chance to develop the courage and fortitude to make the right choice.


10 Comments:
Just my rambling thoughts on this . . . I think it's so good to have these things well thought-out ahead of time, so that when or if the question comes someday in the future, we are well prepared to answer it with conviction. It's not being prepared that makes us more likely to falter and make the decision that might go against our belief system. Maybe it's like practising my trombone. If I tackle that harder passage in a piece of music over and over again until I have it down good, when it comes time for the show, I am far less likely to screw it up. And so it goes for the difficult questions we're asked, if we go over them and debate them and answer them ahead of time, we we're less likely to screw them up.
He's a really good example for all of us.
Wesley, the good news is, I doubt this will be an issue with this technology (which BTW, is YEARS away if ever).
I am almost certain they are using PROGENITOR cells,i.e./BLOOD/BONE MARROW ,which equates to NON EMBRYONIC.
I never trust Times OnLine, especially on anything ethical or Catholic related.
Also, this is old news at EyeCyte, probably intented (by Times Online) to now use the blind to be cheerleaders for killing embryos (intended dupe). I don't think this has anything to do with embryos, nor is it any "big or breaking news", as TO would like all to believe. Progenitor cells have been very promising in a lot of areas.
As for Pfizer, go to Eyecyte.com and read their disclaimer. Three million in biotech is not a lot of money, especially for Pfizer. If using progenitor cells as I suspect, it would seem a reasonable investment and amount from Pfizer.
Also, this press release is from a year ago
http://www.biospace.com/news_story.aspx?NewsEntityId=101188
My best guess: this is intended to keep the flame burning and many deceived about ESC's.
I'm glad you posted it because it brings home again how intentionally deceptive the media is.
As for your original intention of the post, I would NEVER take ESC therapy for anything, for any reason, including life saving. I do wonder how we are going to be assured, when 'adult' therapies do become available, that human embryos weren't involved in the research, being unethical research equates to unethical therapies.
But then, I suspect many are unaware that the polio vaccine came about via fetal research.
p.s. Wesley, forgot to add; long time reader, first time posting. Thanks for this much appreciated amazing blog!
pdill
My immediate question was: Why is there any necessity for this to be done using embryonic stem-cells as opposed to adult stem-cells and/or iPSC's? And what about cancer risk with embryonic cells? Something smells fishy here. pdill is suggesting, if I understand him correctly, that it's actually outright deception, that these are _not_ embryonic stem-cells. I would further suggest that if they got something like this to work with ESC's they could do at least as well if not better with non-embryonic stem-cells.
But if that were the only way, to answer the post's question, yes, I would reject the treatment.
Lydia: you have the order backward. The research to use stem cells to cure macular degeneration was all done using adult stem cells. The whole research program used them, and with good results.
But then, as they started to move to larger clinical trials with more people involved they started to run into all kinds of problems. In the end, the research was completely restarted "from scratch" using embryonic stem cells. It was in Google news a year or two ago. I assume that the embryonic stem cell research has now moved forward enough so that it needs big corporate cash to run the big clinical trials. Macular degeneration is a common cause of blindness in the aged, so there is a lot of money to be made there.
I remember this news, because it was the earliest evidence that I knew of, that for some applications, embryonic stem cells would cure things that adult stem cells would not. Do you know of any case where adult stem cells succeeded in curing something where embryonic stem cells had failed?
Joshua Levy
Joshua can you give a reference (from a medical journal, not the news), of this fact? Thanks.
Despite the obvious "hype and hope" the MSM always does with anything ESC, I still fail to understand, knowing the problems/limits of ESC's in patients, how this is possible.
I'm happy to be corrected, but I would like to see a scientific publication. I still think they are using stem cells from human blood/bone marrow, or cord blood.
pdill: Here is a newspaper article. (Not a scientific article.):
http://www.sciencedaily.com/releases/2007/06/070605121040.htm
You can see that they are very specific about using embryonic cells:
"The therapy, using cells derived from human embryonic stem cells to replace the faulty retinal cells that cause AMD, will be developed by the London Project to Cure AMD"
The following quote refers to previous research using adult stem cells (refered to as "the patient's own cells"): "The London Project's approach will involve production of a cell replacement therapy from human embryonic stem cells, which are effective in replacing dysfunctional RPE and photoreceptors found in AMD, leading to a surgical therapy capable of stabilising and restoring vision in the vast majority of patients. Surgical procedures already developed and trialled in a number of patients using the patients' own cells have illustrated that a cell replacement therapy can work."
So you can see the previous work is adult stem cells, while the current work is embryonic stem cells.
http://www.post-gazette.com/pg/09099/961665-115.stm
I saw this article last week, while it is repairing corneas and not retinas, there clearly is utility in using adult stem cells to treat eye disorders, and given iPS cell advancement, the old taunt "anything you can do, I can do better" can probably apply here as well.
Josh you are most kind to follow up, but I’m afraid you have been duped my friend!
Initially I thought this story was about a company out of San Diego (who did get funding from Pfizer) for AMD a year ago). It was only in trying to validate these “sweeping” claims. that BTW, are counter to current technology; I came to realize this is a different company out of England.
Regardless, it’s still MEDIA HYPE. Josh, not only is ESC research “so over”, it’s over for a good reason; it doesn’t work! Are you aware that to date almost 150 otherwise “incurable” diseases have been successfully treated with ADULT stem cells (one of the recent ones, BTW, BLINDNESS)?
The breakthroughs are so astounding (recent diabetes reversal), that the MSM should be charged with “media malpractice.”
I suggest you Google around a bit on “Google blogs”, (type in the disease type and stem cell), and you will be led to many good adult stem cell blogs” that will help you see and understand the reality.
If you are wondering why the MSM does this, know it’s agenda driven. Embryos for research make a great case for abortion, and all else that follows down the slippery slope. The more the public is accepting of chopping up human life for research (especially if it offers 'hope' to 'cure loved ones) in its weakest form, the more we will be able to “adapt” to the “new rules” concerning the rest of human life.
Wesley posted a piece on Oprah and Dr. Oz a few weeks ago. I suggest you go back and watch that video. It was the first big dose of “reality” the public has had concerning how “over and useless” ESC’s are. To be honest, I was shocked that Dr. Oz admitted it on Oprah (suspect Oprah was clueless and never would have allowed it). Good for him to do that in front of 10 million viewers or whatever crazy number Oprah still manages to attract. Wesley also had a great piece in the Sacramento Bee recently regarding the “politics” behind Obama’s lift of federal monies for ESC research.
Lastly Josh, be suspicious of anything that makes “advanced” claims. If I send out a press release saying I will “cure cancer in 5 years”, who should care? Anyone can SAY anything. The bottom line is this. ESC’s cause tumors and major immune rejection problems (for starters). It’s a major problem not likely to be solved if ever, even in “seven years." On the other hand, progenitor cells/bone marrow/cord blood cells, technically “adult” stem cells), have been successfully treating AMD for, interestingly, “seven years.”
All said, if you are looking for a “breakthrough” story of a blindness cure, here’s a great one of a two year old cured of ONH (optic nerve related blindness) in China. Just think, if we hadn’t been so caught up in “ESR politics” in the USA, we would be even further ahead. I shudder to think of the monies wasted, and even more so, the opportunities missed, because of US politics and a pro death agenda.
Here’s the link:
http://www.findingdulcinea.com/news/science/2009/march/China-s-Controversial-Stem-Cell-Treatment-Helps-Blind-Girl-See.html
Like I said before, if you know of anything that has been cured with adult stem cells after embryonic stem cells have failed, please post it!
This "wet" AMD is one example of embryonic stem cells being turned to after adult have failed. You can try to change the subject to Oz, or California or politics or anything you want, but misdirections will do you no good.
Post an example. One is enough.
Joshua Levy
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